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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Curr Opin Virol. 2021 Jul 28;50:23–29. doi: 10.1016/j.coviro.2021.07.003

Figure 1.

Figure 1.

Location of resistance substitutions on the E2 ectodomain structure [PDB 6MEI] [39]. E2 is gray, with the front layer (aa 424–459) and CD81 binding loop (aa 519–535) shaded in pink and AS412 (aa 412–423) shaded in light blue. Location of substitutions conferring resistance to (i) bNAbs targeting front layer/CD81 binding loop (red), (ii) bNAbs targeting AS412 (blue), or (iii) multiple bNAbs targeting distinct antigenic sites (green) are displayed on the surface of E2. V506 (front layer bNAb resistance) is not visible because it is buried within the structure. Positions of resistance substitutions for E1E2 complex bNAbs (L665, I696) as well some substitutions conferring resistance to multiple bNAbs (V400, G401, L403, T404) are not shown because they are truncated or unresolved in the crystal structure.