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. Author manuscript; available in PMC: 2022 Oct 7.
Published in final edited form as: Mol Cell. 2021 Aug 3;81(19):4091–4103.e9. doi: 10.1016/j.molcel.2021.07.006

Figure 1.

Figure 1.

Overview of PROPER-seq experimental pipeline. (A) PROPER-seq starts with SMART-display, that transforms the input cells into a library of RNA-barcoded proteins (the first arrow), followed by INLISE, that transforms the barcoded proteins in a sequencing library, such that the barcodes of interacting protein pairs form a chimeric sequence (the second arrow). (B) Alignment of the barcodes to reveal the identities of the two genes (top track) between which the chimeric sequences (rows) were formed.