FIGURE 6.

P22077 inhibits metastasis and invasion in vivo. (A) Melanoma cells from mice B16F10 were intramuscularly injected into C57BL/6 mice. The tumour‐bearing mice were randomized for intraperitoneal injection of P22077(5 mg/kg) or control as indicated time‐points for 16 days. Representative photographs of Bouin's fixed lung specimens of mice injected with P22077 or vehicle. (B) The bodyweight was measured during the treatment period. (C) The nodules in lung tissue were counted and recorded. The results were shown as the mean tumour volume ±SD, and significant differences were evaluated using a one‐way ANOVA. *p < 0.05 vs control