FIGURE 7.

The E2F1/SKP2/Beclin1 axis was a necessary link for miR‐205‐5p to suppress pulmonary fibrosis. (A) Model diagram of silicosis induction in mice and injection with agomir, Lenti vectors or siRNAs. (B) Detection of miR‐205‐5p expression pattern, and E2F1, SKP2 and Beclin1 protein expression patterns in mouse models. (C) Detection of Col1a1/Col3a1 mRNA expression pattern in mouse models. (D) Detection of LC3 protein expression pattern in the mouse model. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001. Measurement data were analysed by unpaired t test between two groups and one‐way ANOVA among multiple groups