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The mechanism concerning miR‐205‐5p‐targeted E2F1 in CS‐induced silicosis. miR‐205‐5p impaired SKP2‐mediated poly‐ubiquitination of Beclin1 by targeting E2F1. Additionally, our findings demonstrated the protective effect of miR‐205‐5p against silicosis and suggested that miR‐205‐5p/E2F1/SKP2/Beclin1 axis might be a therapeutic target
