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. 2021 Oct 8;11:20076. doi: 10.1038/s41598-021-99581-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) 28-day mortality rates by severity of illness score (SoIS) and lactate level. Both higher SoIS and higher serum lactate levels are consistently associated with higher 28-day mortality rates. (B) Distribution of SoIS in the normal (gray) and high serum lactate (red) group. Patients with normal serum lactate tend to have lower SoIS. SoIS are normalized to allow comparison across the cohorts.