Table 3.
Meta-analysis of baseline laboratory investigations between survivor and non-survivor kidney transplantation recipient.
| Variables | Survivors | Non-survivors | Number of patients reported | Number of studies reporting | Weighted mean difference (95% CI) | p-value from random effects model | I2 index (%) | Q-test p-value | Egger’s test p-value |
|---|---|---|---|---|---|---|---|---|---|
| Initial serum Cr, mg/dL (mean ± SD) | 1.79 ± 0.88 | 2.19 ± 1.28 | 825 | 5 | 0.50 (− 0.02, 1.03) | 0.06 | 90.9 | < 0.001 | 0.85 |
| Initial eGFR, mL/min/1.73 m2 (mean ± SD) | 44.4 ± 23.3 | 34.4 ± 21.0 | 562 | 3 | − 11.4 (− 15.7, − 7.0) | < 0.001 | 0 | 0.55 | 0.72 |
| Hemoglobin, g/dL (mean ± SD) | 11.6 ± 2.1 | 11.4 ± 2.2 | 582 | 4 | − 0.3 (− 0.9, 0.2) | 0.22 | 34.0 | 0.20 | 0.09 |
| Platelet, × 103/μL (mean ± SD) | 199 ± 66 | 172 ± 115 | 825 | 5 | − 18.5 (− 39.8, 2.8) | 0.09 | 60.1 | 0.030 | 0.18 |
| WBC, × 103/μL (mean ± SD) | 6.42 ± 2.76 | 7.90 ± 3.80 | 525 | 4 | 1.61 (− 0.14, 3.36) | 0.07 | 88.0 | < 0.001 | 0.67 |
| Lymphocytes, × 103/μL (mean ± SD) | 1.04 ± 1.03 | 0.77 ± 0.50 | 1,182 | 7 | − 0.06 (− 0.15, 0.02) | 0.16 | 34.5 | 0.02 | 0.004 |
| Lactate dehydrogenase, U/L (mean ± SD) | 304.0 ± 85.3 | 425.1 ± 205.3 | 473 | 3 | 117.4 (− 13.2, 248.0) | 0.078 | 96.1 | < 0.001 | 0.94 |
| C-reactive protein, mg/dL (mean ± SD) | 5.66 ± 8.23 | 10.50 ± 9.42 | 830 | 5 | 4.85 (1.18, 8.52) | 0.010 | 88.9 | < 0.001 | 0.18 |
| D-dimer, μg/mL (mean ± SD) | 1.29 ± 1.36 | 1.67 ± 1.53 | 525 | 4 | 0.37 (− 0.22, 0.96) | 0.22 | 88.6 | 0.002 | 0.87 |
| Procalcitonin, ng/mL (mean ± SD) | 0.20 ± 0.57 | 0.97 ± 1.48 | 525 | 4 | 0.60 (0.36, 0.83) | < 0.001 | 64.5 | 0.031 | 0.77 |
| Ferritin, ng/mL (mean ± SD) | 893 ± 1294 | 1232 ± 1041 | 634 | 5 | 128.5 (− 276.1, 533.1) | 0.53 | 71.5 | 0.019 | 0.001 |
| IL-6, pg/mL (mean ± SD) | 31.3 ± 35.1 | 126.0 ± 178.7 | 473 | 3 | 95.4 (54.0, 136.8) | < 0.001 | 76.1 | 0.006 | 0.86 |
Cr creatinine, eGFR estimated glomerular filtration rate, WBC white blood cell.