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. 2021 Oct 8;11:20012. doi: 10.1038/s41598-021-99404-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-viral activity of GCPQs against SARS-CoV-2. Virus replication was evaluated using RT-qPCR. The data are presented as a number of RNA copies per mL of the original sample (left) or as Log Removal Value (LRV) compared to untreated samples (right). Non-toxic concentrations were tested (10 μg/ml of GCPQa, 25 μg/ml for GCPQc, and 200 μg/ml for GCPQb and GCPQd). The assay was performed in triplicate, and average values with standard errors are presented. For the RNA copies per mL data GCPQa and GCPQc are significantly different from PBS treated cells (p < 0.0001) and for the log removal value, GCPQa is significantly different from PBS treated samples in the A549 and Vero E6 cell lines (p < 0.05).