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. 2021 Oct 8;12:5892. doi: 10.1038/s41467-021-26162-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Lipophilicity potential mapped to surface representations of yeast (left), human (middle), and fly (right) as viewed as (i) homodecamer assembly from the cytosol, (ii) individual protomers, or (iii) transparent overlay over zoomed in cartoon representation of the central α1-α2 helices. Surfaces are colored from hydrophilic (dark cyan) to hydrophobic (gold). Lipophilicity potential was generated from the mlp command of ChimeraX. B Side view of the luminal domains of yeast, human (PDB 6DS5) and fly (PDB 6MLU) Seipin in relation to the plane of the ER membrane (indicated by a dotted line). C Charge distribution of the yeast Sei1 central helices (α1, α2), depicted as a transparent Coulombic electrostatic potential surface representation (Red, negative charge; blue, positive charge; white, no charge) overlayed over a cartoon representation (light blue) to show acidic side chains. Electrostatic potential was generated from the coulombic command of ChimeraX. D Top View of coarse-grained MD simulations of Sei1 in a POPC membrane with 3% trioleylglycerol. Images depict average lipid number density of trioleylglycerol. Inset – zoom in of corresponding box showing positions of TM1 and TM2.