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. 2021 Oct 8;12:5892. doi: 10.1038/s41467-021-26162-6

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© The Author(s) 2021

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Fig. 6 — Sequential TAG interactions mediate LD assembly by the Sei1-Ldb16 complex. In the ER bilayer, TAG molecules (blue) concentrate in proximity of Seipin oligomers (orange) via weak interaction with Sei1 TMs. TAG molecules within the ring interact strongly with Ldb16 (green) hydroxyl-containing residues, facilitating TAG coalescence and lens formation (see text for details).