Fig. 6. Inhibition of the glucocorticoid and progesterone receptor affects serum-induced resetting.

a PTCs of cultures in response to different concentrations of rat serum (RS), with or without pretreatment of 1.25 µM mifepristone (MF). (Pink: type-1 resetting model ±95% confidence interval, ns not significant (p > 0.05) in bootstrapping test for response, n = 102, 126, 155, 161, 162, 212, 235, 166, 143, 173 cells per condition, respectively). b Model selection for each treatment across the tested concentrations. Dots represent the observed RMSE₀–RMSE₁, error bars represent the 95% confidence interval from bootstrapping test. Filled dots stand for significant type-0 fit according to bootstrapping test. c Maximal phase advance (left) and maximal phase delay (right) for each treatment across the tested concentrations. Empty dots represent nonsignificant phase shifts based on bootstrapping test. (*p < 0.05, two-sided bootstrapping test for the difference in maximal shift between two conditions). d Phase of maximal shift induced by 0.4% RS with and without MF. Source data are provided as a Source Data file and in Supplementary Dataset 6.