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. 2021 Oct 8;12:5902. doi: 10.1038/s41467-021-26161-7

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© The Author(s) 2021

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Fig. 3 — a–c Surface and ribbon representations of the transmembrane domains (TMD). EM densities of the lipids are indicated with an arrow. a EM density resembling a lipid is located in between TM1/2/11. b Orthogonal view. c Most probable orientation of the lipid (black) between TMD1 and TMD2. N- and C- halves of ABCA4 are colored as dark green and light green, respectively. d–f Surface and ribbon representations of the exocytoplasmic domains, showing (d) the tunnel that is accessible from the lumen side. e EM density was also found on the opposite side of the exocytoplasmic domain (ECD), indicated as purple mesh. f Orthogonal view of ECD showing the EM densities (arrow).