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. 2021 Oct 8;12:5902. doi: 10.1038/s41467-021-26161-7

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© The Author(s) 2021

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Fig. 5 — a UV-Vis spectra of ABCA4 in its unbound (black line) and bound state (gray line) normalized at 280 nm. The peak absorbance (λ_MAX = 362 nm) corresponds to N-Ret-PE bound to ABCA4. b N-Ret-PE associated electron microscope (EM) density is shown as blue mesh, with σ = 6.0, and displays the substrate in a transverse position, wedged between the transmembrane domains (TMD) and exocytoplasmic domain (ECD). c View from the lumen side of the membrane showing N-Ret-PE with the β-ionone group of the all-trans-retinal moiety close to TM8/11 and the phosphate group close to TM2/5. d View from the cytoplasmic side of the membrane showing bound substrate close to the B-loop of ECD1.