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. 2021 Oct 9;159:78–86. doi: 10.1016/j.ejca.2021.09.027

Table 1.

Demographic data of children with cancer or after haematopoietic stem cell transplantation and SARS-CoV-2 infection confirmed by PCR.

Demographic data N = 131
Median age, (IQR) 8 (4–14)
Male sex, n (%) 75 (57)
Country, n (%)
  • -

    Austria

 10 (8)
  • -

    Germany

 26 (20)
  • -

    Italy

 5 (4)
  • -

    Switzerland

 2 (1.5)
  • -

    UK

 2 (1.5)
  • -

    Brazil

 41 (31)
  • -

    Canada

 21 (16)
  • -

    Russia

 12 (9)
  • -

    Israel

 9 (7)
  • -

    Australia

 3 (2)
Underlying diagnosis, n (%)
  • -

    Leukaemia

 60 (46)
  • -

    Lymphoma

 18 (14)
  • -

    Solid tumour

 48 (37)
  • -

    HSCT for primary immunodeficiency

 5 (4)
Active cancer treatment, n (%) 100 (76)
  • -

    Intensive chemotherapy, n

 31a
GVHD, n (%)
  • -

    Acute (Grade 1, n = 1; Grade 2, n = 1)

 2 (2)
  • -

    Chronic

 2 (2)
  • -

    Unknown

 1 (0.8)
CAR-T treatment, n (%) 3 (2)
No comorbidity, n (%) 96 (73)
At least one comorbidity 35 (27)
  • -

    Overweight (BMI >95th percentile)

 8
  • -

    Panhypopituitarism or adrenal insufficiencyb

7
  • -

    Chronic neurological diseasec

5
  • -

    Chronic lung disease (other than asthma)

 4
  • -

    Hypertension

 4
  • -

    Diabetes (including steroid-induced)

 2
  • -

    Asthma

 2
  • -

    Hypogammaglobulinemia

 2
  • -

    Other chronic diseased

7
Bacterial coinfection (n = 5)
  • -

    Blood stream infection

 4
  • -

    E coli urinary tract infection

 1
  • -

    S. aureus soft tissue infection

 1
  • -

    Mycobacterium tuberculosis peritonitis

 1
Viral coinfection (n = 5)
  • -

    Cytomegalovirus (blood)

 2
  • -

    Enterovirus/rotavirus enteritis

 1
  • -

    Parainfluenza respiratory tract infection

 1
  • -

    Herpes simplex virus gingivostomatitis

 1
Invasive fungal infection (n = 3)
  • -

    Disseminated aspergillosis

 1
  • -

    Pneumocystis jirovecii pneumonia

 1
  • -

    Candida tropicalis urinary tract infection

 1
Median neutrophil count, cells/mm3 (IQR) 805 (155–2020)
Median lymphocyte count, cells/mm3 (IQR) 530 (190–1030)

IQR, interquartile range; GVHD, graft versus host disease; BMI, body mass index.

a

Unknown in n = 43.

b

Includes children with brain tumour affecting the pituitary stalk (n = 4) or long-term immunosuppression (n = 3).

c

All patients in whom the tumour has caused brain damage.

d

Includes patients with Down syndrome, psoriasis, xeroderma pigmentosum, Niemann-Pick disease, kidney transplantation, Kaposi sarcoma and Russel's syndrome.