The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of antifungal resistance.

Despite the need for more antifungal drug options, no new classes of antifungal drugs have become available over the last two decades, but there is finally hope on the horizon, with a number of new antifungal classes in late-stage clinical development.

In this review, we discuss the most promising antifungal drugs in development, focusing on the mechanism of action and pharmacokinetics, as well as the spectrum of activity and stages of clinical development.

We also highlight the potential future role of these drugs and unmet needs.