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. 2021 Sep 20;2(10):100230. doi: 10.1016/j.jtocrr.2021.100230

Figure 4.

Figure 4

(A–D) H&E staining (×100) and multiplex immunohistochemistry images from untreated brain metastasis specimens (n = 19) and treated with radiation specimens (n = 3). Staining as indicated and similar to Fig. 1. (E) Relationship of the density of each immune cell in the cancer area and the stromal area between untreated and postradiation brain metastasis specimens. (F, G) Multiplex immunohistochemistry images of PD-L1 expression on cancer cells among them. (H) Relationship of the density of PD-L1 expression on cancer cells between untreated and postradiation brain metastasis specimens. CD204+, CD204-positive; CD4+, CD4-positive; CD8+, CD8-positive; Foxp3+, Foxp3-positive; H&E, hematoxylin and eosin staining; PD-L1, programmed death-ligand 1.