Table 2.

Interaction difference between the wild type and mutant complexes.

Complexes	Hydrogen Bonds	Salt Bridges
Wild Type	Gln493–Glu35, Lys417–Glu30, Thr500–Tyr41, Thr500–Asn330, Gln498–Gln42, Gln498–Lys353, Tyr449–Glu38, Gly496–Glu38, Gly496–Lys353, Gly502–Lys353	Glu30–417
N439K	Glu32-Lys439, Ser19-Ala475, Tyr83-Asn487, Glu35-Gln493, Asn330-Thr500, Tyr41-Thr500, Gln42-Gly446, Gln42-Tyr449, Glu38-Tyr449, Lys353-Gln498, Lys353-Gly496, Lys353-Gly502	Lys439–Glu329, Glu30–Lys417
S477N	Glu30-Lys417, Tyr83-Asn487, Tyr83-Tyr489, Glu329-Lys439, Asn330-Thr500, Gln42-Tyr449, Tyr41-Thr500, Glu35-Gln493, Glu38-Tyr449, Lys353-Gln498, Lys353-Gly496, Lys353-Gly502	Lys439–Glu329, Glu30–Lys417
T478K	Gln42–Gly446, Gln42–Tyr449, Ser19–Ala475, Tyr83–Asn487, Tyr83–Tyr489, Lys353–Gly496, Lys353–Gln498, Asn330–Thr500, Tyr41–Thr500, Glu38–Tyr449, Glu35–Gln493, Gln42–Gln498, Glu38–Gln498, Tyr41–Asn501, Lys353–Gly502	Glu30–417