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. 2021 Oct 8;40:315. doi: 10.1186/s13046-021-02120-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — MUS81 overexpression links with poor prognosis and WEE1 deficiency in gastric cancer. a Heatmap of differentially expressed genes (DEGs) between gastric cancer and paracancerous tissues in the GSE62254 data set. The top 10 upregulated genes and top 10 downregulated genes are shown. b Volcano map of DEGs related to DNA damage and repair. The DEGs with ∣log (FC)∣ > 0.05 and -log (P-value) >1 are indicated; red, green, and yellow dots represent upregulated DEGs, down-regulated DEGs, and DEGs with non-significant changes, respectively. c High expression of MUS81 is associated with short overall survival time in patients with gastric cancer (GSE62254 data set). d Pearson correlation analysis of MUS81 and WEE1 in the GSE62254 data set. e Representative immunohistochemical staining of MUS81 and WEE1 in patients with gastric cancer. Scale bar: 100 μm. f Pearson correlation analysis was performed to validate the correlation of MUS81 and WEE1 protein expression in 26 patients with gastric cancer from Wuhan Union Hospital