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. 2021 Oct 8;40:315. doi: 10.1186/s13046-021-02120-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Targeting MUS81 sensitizes the anticancer effect of WEE1 inhibitor MK1775 in gastric cancer in vitro and in vivo. a and b MTT assay was performed to examine the effect of MK1775 on proliferation of MUS81 knockdown and parental gastric cancer cells SGC7901 and BGC823. Data are reported as mean ± SD for five independent experiments. c Clonogenic assay was performed to detect the anticancer effect of MK1775 in MUS81 knockdown and parental gastric cancer cells SGC7901 (left) and BGC823 (right). Representative images are displayed. d Data of the clonogenic assay in SGC7901 (left) and BGC823 (right) cells are reported as mean ± SD for three independent experiments. e The image of tumors in the SGC7901 gastric cancer xenograft mice model (n = 6 for each group) after treatment for 16 d. f Tumor growth curve of indicated groups in the SGC7901 gastric cancer xenograft mice model. The data are presented as mean ± SD (n = 6 for each group). g Tumor volume on day 16 after treatment. Data are presented as mean ± SD (n = 6 for each group). h Representative images of immunohistochemical (IHC) staining of Ki67 in the gastric cancer xenograft mice model. Scale bar: 25 μm. i IHC staining analysis of Ki 67-positive cells in different groups. The data are presented as mean ± SD (n = 3). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001; ns., not significant