Table 2.
Results of EWASs of CHD risk factors in blood with incident CHD follow-up
| Authors | Traits of interest in EWASs | Sample size | Ancestry | Array type | CpGs | Genes | Gene/RNA/protein full names |
|---|---|---|---|---|---|---|---|
| Aslibekyan et al. 2018 [37] | TNF-α | Discovery: 4794 | Discovery: European | 450k array | cg16411857 | NLRC5 | NLR family CARD domain containing 5 |
| Replication: 816 | Replication: European | cg07839457 | |||||
| iCHD: 1895 cases, ≤ 9566 controls | iCHD follow-up: multiple ancestries | cg00959259 | DTX3L; PARP9 | Deltex E3 ubiquitin ligase 3L | |||
| cg08122652 | Poly(ADP-ribose) Polymerase family member 9 | ||||||
| Hedman et al. 2017 [38] | TG, HDL-cholesterol | Discovery: 2306 | European | 450k array | cg27243685 | ABCG1 | ATP binding cassette subfamily G member 1 |
| Replication: 2025 | |||||||
| iCHD: 193 cases, ≤ 2113 controls | |||||||
| Campanella et al. 2018 [42] | Waist-to-height ratio | Discovery: 1941 | European | 450k array | cg12593793 | LMNA | Lamin A/C |
| Replication: 358 | |||||||
| iCHD: 131 cases, 195 controls | |||||||
| Fernández-Sanlés et al. 2018 [46] | Age-independent cardiovascular risk | Discovery: 645 | European | 450k array | cg12547807 | LOC100506022 | Long intergenic non-protein coding RNA 02606 |
| Replication: 2542 | |||||||
| iCVD: 222 cases, ≤ 1950 controls | cg27537125 | MIR4425 | MicroRNA 4425 | ||||
| cg05951221 | AC068134.6; ALPPL2 | / | |||||
| cg21566642 | Alkaline phosphatase, placental-like 2 | ||||||
| cg05575921 | AHRR | Aryl-hydrocarbon receptor repressor | |||||
| cg19939077 | PPIF | Peptidylprolyl isomerase F | |||||
| cg00574958 | CPT1A | Carnitine palmitoyltransferase 1A | |||||
| cg18608055 | SBNO2 | Strawberry notch homolog 2 |