Table 3.
Selected overlapping signals between EWASs of iCHD or with iCHD follow-ups, and EWASs of CVD risk factors and CVD-related traits
| iCHD DNA methylation signals | CVD or CHD risk factors EWAS signals identified the same gene | |||
|---|---|---|---|---|
| Study | Gene (CpG site, GRCh37/hg19 location) | Study | Phenotype/disease | Locus |
| Westerman et al. 2019 [30] | SLC1A5 (Intragenic region consisting of 6 CpG sites located in chr19: 47287777–47288263) | Hedman et al. 2017 [38] | TG levels | cg02711608, 5′UTR/body |
| Richard et al. 2017 [58] | Systolic and diastolic blood pressure | cg02711608, 5′UTR/body; cg22304262, 5′UTR/body | ||
| TNRC6C (Intragenic region consisting of 6 CpG sites located in chr17: 76037034–760375623) | Abdulrahim et al. 2019 [52] | All-cause mortality | Intragenic region consisting of 6 CpG sites located at chr17: 76037035–76037563 | |
| Agha et al. 2019 [34] | ITGB2 (cg08422803, TSS200/5′UTR) | Ligthart et al. 2016 [49] | CRP levels | cg18663307, 5′UTR/TSS1500 |
| Del Pilar Valencia-Morales et al. 2015 [62] | Atherosclerotic aorta | cg18012089, body | ||
| KANK2 (cg01751802, TSS1500) | Hedman et al. 2017 [38] | HDL-cholesterol levels | *cg01751802, TSS1500 | |
| Zhang et al. 2017 [73] | Cardiac autonomic responses | cg26905268, TSS200 | ||
| ADAMTS2 (cg02683350, body) | Gallego-Fabrega et al. 2016 [74] | Recurrence of ischemic stroke | cg09533145, body | |
| ANO1 (cg24318598, 3′UTR/body) | Rask-Andersen et al. 2016 [23] | Cross-sectional MI | cg15269503, TSS200 | |
| Navas-Acien et al. 2021 [36] | CALHM1 (cg26955383, TSS200) | Mendelson et al. 2017 [75] | BMI | *cg26955383, TSS200 |
| Aslibekyan et al. 2018 [37] | NLRC5 (cg07839457, TSS1500) | Ahsan et al. 2017 [76] | Levels of multiple protein biomarkers of inflammation and cancers | *cg07839457, TSS1500 |
| Hedman et al. 2017 [38] | Total cholesterol levels | *cg07839457, TSS1500 | ||
| Hedman et al. 2017 [38] | ABCG1 (cg27243685, 5′UTR/body) | Pfeiffer et al. 2015 [54] | HDL-cholesterol levels; TG levels | cg06500161, body |
| Demerath et al. 2015 [57] | BMI | cg06500161, body; *cg27243685, 5′UTR/body | ||
| Campanella et al. 2018 [42] | BMI; waist circumference; waist-hip ratio; waist-height ratio | cg06500161, body | ||
| Hidalgo et al. 2014 [55] | Insulin levels; HOMA-IR | cg06500161, body | ||
| Fernández-Sanlés et al. 2018 [46] | ALPPL2 (cg05951221, intergenic region; cg21566642, intergenic region) | Abdulrahim et al. 2019 [52] | All-cause mortality | Intragenic region |
| Zeilinger et al. 2013 [77] | Smoking | *cg21566642, intergenic region | ||
| Fernández-Sanlés et al. 2021 [53] | Cross-sectional MI | *cg21566642, intergenic region | ||
| AHRR (cg05575921, body) | Ligthart et al. 2016 [49] | CRP levels | *cg05575921, body | |
| Zhang et al. 2016 [48] | Smoking | *cg05575921, body | ||
| Fernández-Sanlés et al. 2021 [53] | Cross-sectional MI | *cg05575921, body | ||
| Portilla-Fernández et al. 2021 [50] | Carotid intima-media thickness | *cg05575921, body | ||
| CPT1A (cg00574958, 5′UTR) | Hedman et al. 2017 [38] | TG levels | *cg00574958, 5′UTR; cg09737197, 5′UTR; cg17058475, 5′UTR | |
| Pfeiffer et al. 2015 [54] | TG levels | *cg00574958, 5′UTR | ||
| Irvin et al. 2014 [56] | TG levels | *cg00574958, 5′UTR | ||
| Demerath et al. 2015 [57] | BMI | *cg00574958, 5′UTR | ||
| Richard et al. 2017 [58] | Systolic and diastolic blood pressure | *cg00574958, 5′UTR | ||
| SBNO2 (cg18608055, body) | Ligthart et al. 2016 [49] | CRP levels | *cg18608055, body | |
| Ek et al. 2016 [60] | GDF-15 levels | *cg18608055, body | ||
| Kazmi et al. 2019 [78] | Hypertensive disorder of pregnancy | cg07573872, body | ||
‘*’Denotes that the CpG site is the same as that identified in the EWAS of iCHD or with iCHD follow up