Table 3.
Results of the over-representation analysis using the Reactome database
| Term | # | Genes | p-value |
|---|---|---|---|
| Neuronal system | 28 | ABAT, ACE, CDH8, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HOMER1, HTR3A, KCNJ10, MAOA, NLGN4X, NLGN4Y, NRXN1, NRXN2, PRKCB1, DLG4, SHANK2, SHANK3, SLC6A4, SNAP25, STX1A | 1.11 × 10−16 |
| Neurexins and neuroligins | 11 | GRIN2A, GRIN2B, HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A | 6.25 × 10−14 |
| Transmission across Chemical Synapses | 20 | ABAT, ACE, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, MAOA, PRKCB1, DLG4, SLC6A4, SNAP25, STX1A | 7.85 × 10−12 |
| Protein–protein interaction at synapses | 11 | GRIN2A, GRIN2B HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A | 1.41 × 10−11 |
| Transcriptional Regulation by MECP2 | 5 | BDNF, GRIN2A, GRIN2B, MECP2, MET | 4.91 × 10−10 |
| MECP2 regulates neuronal receptors and channels | 4 | GRIN2A, GRIN2B, MECP2, MET | 1.56 × 10−9 |
| Neurotransmitter receptors and postsynaptic signal transmission | 14 | EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, PRKCB1, DLG4 | 1.72 × 10−9 |
| GABA receptor activation | 8 | EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, KCNJ10 | 2.99 × 10−8 |
The most significant pathways, according to p-value, are included