REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Integrin β1 (D2E5)	Cell Signaling Technology	Cat#9699; RRID:AB_11178800
Integrin β1 (12G10)	Abcam	Catab30394
Integrin β1 (CD29)-BV510	BD Biosciences	Cat#747747; RRID:AB_2868388
Integrin α1 (CD49a) Alexa 647	Biolegend	Cat328310; RRID:AB_2129242
Integrin α2	Abcam	Catab181548; RRID:AB_2847852
Integrin α2 (CD49b)-FITC	BD Biosciences	Cat555498; RRID:AB_395888
Integrin α2 (CD49b)-Alexa 647	BD Biosciences	Cat564314; RRID:AB_2738739
E-Cadherin (24E10)	Cell Signaling Technology	Cat3195; RRID:AB_2291471
K48-linkage Specific Polyubiquitin (D9D5)	Cell Signaling Technology	Cat4289; RRID:AB_10557239
HA-Tag	Cell Signaling Technology	Cat3724; RRID:AB_1549585
AnnexinV-FITC	Biolegend	640906
Tubulin	Cell Signaling Technology	Cat2148; RRID:AB_2288042
GAPDH	Santa Cruz	Catsc47724; RRID:AB_627678
PARP	Cell Signaling Technology	Cat9542; RRID:AB_2160739
Cleaved PARP	Cell Signaling Technology	Cat9541; RRID:AB_331426
ATF-6	Cell Signaling Technology	Cat65880; RRID:AB_2799696
IRE1α	Cell Signaling Technology	Cat3294; RRID:AB_823545
Actin	Sigma-Aldrich	CatA5441; RRID:AB_476744
SignalStain®Boost IHC Detection Reagent (HRP, Mouse)	Cell Signaling Technology	Cat8125; RRID:AB_10547893
SignalStain®Boost IHC Detection Reagent (HRP, Rabbit)	Cell Signaling Technology	Cat8114; RRID:AB_10544930
Anti-mouse IgG, HRP-linked Antibody	Cell Signaling Technology	Cat7076; RRID:AB_330924
Anti-rabbit IgG, HRP-linked Antibody	Cell Signaling Technology	Cat7074; RRID:AB_2099233
Sambucus Nigra Lectin (Agarose bound)	Vector Laboratories	AL-1303-2
Chemicals, peptides, and recombinant proteins
Collagen type I (from Human placenta)	Sigma-Aldrich	C7774
Collagen type III (From human placenta)	Advanced BioMatrix	5019
Collagen type IV (From Human Cell)	Sigma-Aldrich	C7521
Fibronectin from Human Plasma	Millipore	FC010
Laminin (From EHS murine sarcoma)	Sigma-Aldrich	L2020
DAPI	BD Biosciences	564907
FITC Annexin V Apoptosis Detection Kit I	BD Biosciences	556547
Pierce™ BCA Protein Assay Kit	ThermoFisher Scientific	23225
Diaminobenzidine substrate kit (DAB)	ThermoFisher Scientific	34002
ProLong® Gold antifade reagent	Cell Signaling Technology	9071
Radioimmunoprecipitation assay buffer (RIPA)	Cell Signaling Technology	9806
Thiazolyl Blue Tetrazolium Bromide (MTT)	Sigma-Aldrich	M2128
Agarose, low gelling temperature	Sigma-Aldrich	A9414
Fetal Bovine Serum	Sigma-Aldrich	F7524
Bovine serum albumin	Sigma-Aldrich	A9418
Proteinase Inhibitor Cocktails	Sigma-Aldrich	P8340
Cell-dissociation solution non-enzymatic	Sigma-Aldrich	C5914
MG132	Sigma-Aldrich	M8699
Cycloheximide	Sigma-Aldrich	C4859
Tunicamycin	Sigma-Aldrich	T7765
pGEM®-T Easy Vector System	Promega	A1360
Wizard® SV Gel and PCR Clean-Up System	Promega	A9281
Pfu DNA Polymerase	Promega	M7741
Sequencing-grade modified trypsin	Promega	V5111
jetPEI DNA transfection reagent	Polyplus-transfection	101-10N
Trans IT-X2 transfection reagent	Mirus	MIR6004
Q5 Site-Directed Mutagenesis Kit	New England Biolabs	E0554S
PNGase F	New England Biolabs	P0708L
Experimental models: Cell lines
IGROV1	ATCC	RRID:CVCL_1304
SK-OV-3	ATCC	RRID:CVCL_0532
OVCAR3	ATCC	RRID:CVCL_0465
OVCAR4	Oncotest GmbH	RRID:CVCL_1627
OVCAR5	Oncotest GmbH	RRID:CVCL_1628
OVCAR8	Oncotest GmbH	RRID:CVCL_1629
CAOV3	ATCC	RRID:CVCL_0201
BG1	Oncotest GmbH	RRID:CVCL_6571
SKOV3.ip1		RRID:CVCL_0C84
Oligonucleotides
ITGA2 N105Q For AAGCATTCCAcaaGTTACTGAGATG	This paper	NA
ITGA2 N105Q Rev GTTGAAGTTTGCAAATTTAGTTTTTC	This paper	NA
ITGA2 N112Q For GATGAAAACCcaaATGAGCCTCG	This paper	NA
ITGA2 N112Q Rev TCAGTAACATTTGGAATGC	This paper	NA
ITGA2 N343Q For ATACTTTTTCcaaGTGTCTGATGAAGC	This paper	NA
ITGA2 N343Q Rev CTTTCTGTTGGAATACTAGC	This paper	NA
ITGA2 N432Q For GCAGGACAGAcaaCACAGTTCATATTTAG	This paper	NA
ITGA2 N432Q Rev AGAATTTGGTCAAAGGCTTG	This paper	NA
ITGA2 N460Q For TCCTCGGGCAcaaTATACCGGCC	This paper	NA
ITGA2 N460Q Rev GCACCAGCAACAAAGTGAG	This paper	NA
ITGA2 N475Q For TGAGAATGGCcagATCACGGTTATTC	This paper	NA
ITGA2 N475Q Rev TTCACACTATATAGCACTATCTGG	This paper	NA
ITGA2 N699Q For CATTGTATATcaaATCACACTTGATGC	This paper	NA
ITGA2 N699Q Rev GCCACTTGATTGTTTTGC	This paper	NA
ITGA2 N1057Q For TTCCTGTAGTcaaGTTACCTGCTG	This paper	NA
ITGA2 N1057Q Rev GCAGTTCTGCAGTTCAATTC	This paper	NA
ITGA2 N1074Q For ATACTTTGTTcaaGTGACTACCAGAATTTG	This paper	NA
ITGa2 N1074Q Rev TCTCCTTTCATGTGAACG	This paper	NA
ITGA2 N1081Q For CAGAATTTGGcaaGGGACTTTCG	This paper	NA
ITGA2 N1081Q Rev GTAGTCACTTGAACAAAGTATTC	This paper	NA
ITGA2 614F Sequencing primer GCCCCACAAAGACACAGGT	This paper	NA
ITGA2 1990F Sequencing primer ACCGATGTGTCTATTGGTGCC	This paper	NA
ITGA2 2003R Sequencing Primer TGGTCAACAAGAATGCTCAGA	This paper	NA
ATF-6 For QPCR TTGACATTTTTGGTCTTGTGG	Balakrishnan et al., 2013	NA
ATF-6 Rev GCAGAAGGGGAGACACATTT	Balakrishnan et al., 2013	NA
PERK For TCATCCAGCCTTAGCAAACC	Balakrishnan et al., 2013	NA
PERK Rev ATGCTTTCACGGTCTTGGTC	Balakrishnan et al., 2013	NA
IRE1a For CTCTGTCCGTACCGCCC	Balakrishnan et al., 2013	NA
IRE1a Rev GAAGCGTCACTGTGCTGGT	Balakrishnan et al., 2013	NA
Recombinant DNA
pUltra	Addgene	24129
pUltra-Chili	Addgene	48687
pCMVR8.74	Addgene	22036
pMD2.G	Addgene	12259
mCherry-Integrin-Alpha2-N-18	Addgene	55063
pUltra-Chili-ITGA2-HA	Huang et al., 2020	NA
pUltra-Chili-ITGA2-HA (KOR)	Huang et al., 2020	NA
pUltra-Chili-ITGA2-N3NQ-HA	This paper	NA
pUltra-Chili-ITGA2-I4NQ-HA	This paper	NA
pUltra-Chili-ITGA2-C3NQ-HA	This paper	NA
pUltra-Chili-ITGA2-10NQ-HA	This paper	NA
pCMV3-ST6GAL1-HA	Sino Biological Inc	HG11590-CY
pUltra-ST6GAL1	This paper	NA
Software and algorithms
R studio 4.0.3	R Core Team, 2017	https://www.R-project.org/
GraphPad Prism 9	Pad Software, Inc.	https://www.graphpad.com/
ImageJ	NIH	https://imagej.nih.gov/ij/
FlowJo v10	Becton Dickinson	https://www.flowjo.com/
Byonic 2.16	Protein Metrics	https://proteinmetrics.com/
Image Lab 6.0.1	Bio-Rad	https://www.bio-rad.com/
Skyline 20.1	MacCoss Lab	https://skyline.ms/
SafeQuant v2.3.4	Ahrne et al., 2016	https://github.com/eahrne/SafeQuant/)
ReactomePA	Yu and He, 2016	NA
Progenesis QI 2.0	Waters	https://www.nonlinear.com/
OMERO v5.6	OME project	https://www.openmicroscopy.org/omero
Adobe illustrator 2021	Adobe	https://www.adobe.com/ch_de/?mv=search&sdid=88X75SKX