Fig. 4.

(A) Macrocyclization of 3a to 3e: matched and mismatched effect. ^aIsolated yields. ^bEnantiomeric ratios were determined using chiral high-performance liquid chromatography analysis. ^cDiastereomeric ratio (dr) was determined by ¹H NMR in CD₂Cl₂. (B) Macrocyclization of aminophenol 3f using different ligands. ^d4f is observed as a 2.5:1 mixture of diastereomers at 25 °C in CD₂Cl₂ by ¹H NMR. ^e5f is observed as a 4.3:1 mixture of diastereomers. ^fProduct distribution based on uncorrected peak integration on ultraperformance liquid chromatography–mass spectrometry (UPLC-MS) peaks. See SI Appendix, section 14 for UPLC-MS traces.