Textbox 1: Case definitions applied in the cohort study of post-weaning diarrhea

1. ETEC-associated diarrhea
Diarrhea
Abundant growth of hemolytic E. coli
The considered E. coli-like phenotype is confirmed to carry genes for fimbria (F4 and/or F18) and toxins (STa, STb and/or LT)
2. Hemolytic non-ETEC E. coli associated diarrhea
Diarrhea
Abundant growth of hemolytic E. coli
The considered E. coli-like phenotype is not carrying genes for both fimbria (F4 or F18) and toxins (STa, STb, and/or LT)
3. Rotavirus-associated diarrhea:
Diarrhea
Ct-value < 33 for rotavirus A
4. ETEC- and Rotavirus-associated diarrhea
Fulfills both the case-definition for ETEC-associated diarrhea and Rotavirus-associated diarrhea
5. Hemolytic non-ETEC E. coli- and Rotavirus-associated diarrhea
Fulfills both the case-definition for Hemolytic E. coli associated diarrhea Rotavirus-associated diarrhea
6. Diarrhea with no detection of pathogens
Diarrhea
Complete test results for both rotavirus and bacteriology is available
Does not fulfill the criteria for ETEC-associated diarrhea, hemolytic E. coli associated diarrhea, or Rotavirus-associated diarrhea
7. Diarrhea with unknown etiology
Diarrhea
Missing test results for either rotavirus or bacteriology, and no reasonable imputations could be made