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Nuclease prime editing in hard-to-edit cell lines. (A) PEA1-Nuc editing efficiencies of targeted 1- or 3-bp insertions, 1- or 3-bp deletions and point mutations in K562 cells. (B) PEA1-Nuc editing efficiencies in HeLa cells. Mean ± SD, n = 3, except for RNF2 +3–5 GAG del and VEGFA +1 T to G in K562 which were n = 2. (C) Example of partial template duplications (PTDs) observed in HEK3 +1 CTT ins nuclease prime edited cells.
