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. 2021 Sep 17;49(18):10785–10795. doi: 10.1093/nar/gkab792

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Prime editing PE3 and PE-nuclease in mouse embryonic stem (ES) cells. (A) Editing efficiency of PE3 system for creating small edits using PEA1 vector. (B) Editing efficiency of PE-nuclease for creating small edits using PEA1-Nuc vector. (C) Editing efficiency of loxP insertions into the EphB2 locus using PEA1 and PEA1-Nuc mean ± SD, n = 3. ‘Any loxP’ was defined as alleles containing the full length of loxP sequences with or without extra modifications.