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. 2021 Sep 22;49(18):10235–10249. doi: 10.1093/nar/gkab807

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Structure of FOX-DBD. (A) Overall structure of FOX-DBD. The figure shows the structure of FOXM1 (PDB code: 3G73). Structural cartoons are colored by conservation. (B) Topology of FOX-DBD. Both the S1 and H4 are only presented in certain FOX-DBDs. (C) Different wing2 conformations of FOX-DBDs. The PDB codes for FOXO3, FOXN1, FOXK1 and FOXG1 are 2UZK, 6EL8, 2C6Y and 7CBY, respectively. (D) Structural comparison between human FOXA3-DBD (PDB code: 1VTN) and human histone H1 globular domain (PDB code: 6HQ1).