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. 2021 Sep 22;49(18):10235–10249. doi: 10.1093/nar/gkab807

Figure 5.

Figure 5.

DNA-binding-induced conformational change of FOX-DBD. DNA-bound structures are shown in color and apo FOX-DBD structures are shown in gray. Major conformational differences are indicated by red arrows. The PDB codes are FOXN1, 6EL8 (DNA-bound) and 5OCN (apo); FOXC2, 6AKO (DNA-bound) and 1D5V (apo); FOXO1, 3CO7 (DNA-bound) and 6QVW (apo); FOXO3, 2UZK (DNA-bound) and 2K86 (apo); FOXO4, 3L2C (DNA-bound) and 1E17 (apo).