Table 1.
Determined FOX-DBD structures
| PDB entry | Protein | DNA Core motif | Method | Resolution (Å) | Assembly | Reference |
|---|---|---|---|---|---|---|
| 5X07 | FOXA2 | GTAAACA | X-ray | 2.80 | Monomer | (61) |
| 1VTN | FOXA3 | TAAGTCA | X-ray | 2.50 | Monomer | (41) |
| 1D5V | FOXC2 | Protein alone | NMR | n/a | Monomer | (81) |
| 6AKO | FOXC2 | GTAAACA | X-ray | 2.40 | Monomer | (59) |
| 6AKP | FOXC2 | GTACACA | X-ray | 2.32 | Monomer | (59) |
| 6O3T | FOXC2 | TGTTTATAAACA | X-ray | 3.06 | Dimer, lack PPI | (82) |
| 6LBM | FOXC2 | GTAAACA | X-ray | 2.84 | Monomer | (83) |
| 2HFH | Foxd3 (mouse) | Protein alone | NMR | n/a | Monomer | (84) |
| 2HDC | Foxd3 (mouse) | GCTTAAAATAACAATAC | NMR | n/a | Monomer | (58) |
| 7CBY | FOXG1 | GTAAACA | X-ray | 1.65 | Monomer | (44) |
| 2A3S | Foxk1 (mouse) | Protein alone | NMR | n/a | Monomer | n/a |
| 2C6Y | FOXK1 | GTAAACA | X-ray | 2.40 | Dimer, lack PPI | (65) |
| 3G73 | FOXM1 | TGTTTATAAACA | X-ray | 2.21 | Dimer, weak PPIs | (56) |
| 6EL8 | FOXN1 | GACGC | X-ray | 1.61 | Monomer | (66) |
| 5OCN | FOXN1 | Protein alone | X-ray | 2.70 | Monomer | (66) |
| 6NCE | FOXN3 | AGTAAACA | X-ray | 2.60 | Monomer | (67) |
| 6NCM | FOXN3 | GACGC | X-ray | 2.70 | Monomer | (67) |
| 3CO7 | FOXO1 | GTAAACA | X-ray | 2.91 | Monomer | (60) |
| 3CO6 | FOXO1 | GTAAACA | X-ray | 2.10 | Monomer | (60) |
| 3COA | FOXO1 | CAAAACAA | X-ray | 2.20 | Monomer | (60) |
| 5DUI | FOXO1 | ATGATTTACGTAAAATAGAAA | X-ray | 2.31 | Dimer, lack PPI | (85) |
| 4LG0 | FOXO1/ETS1 | AAACAATAACAGGAAACCGTG | X-ray | 2.19 | Heterodimer, no PPI | (5) |
| 6QVW | FOXO1 | Protein alone | NMR | n/a | Monomer | (86) |
| 6LBI | FOXO1 | GTAAACATGTTTAC | X-ray | 3.07 | Dimer, with PPIs | (83) |
| 2UZK | FOXO3 | GTAAACA | X-ray | 2.70 | Monomer | (62) |
| 2K86 | FOXO3 | Protein alone | NMR | n/a | Monomer | (87) |
| 1E17 | FOXO4 | Protein alone | NMR | n/a | Monomer | (88) |
| 3L2C | FOXO4 | CTATGTAAACAAC | X-ray | 1.87 | Monomer | (55) |
| 2KIU | FOXP1 | Protein alone | NMR | n/a | Monomer | (89) |
| 2A07 | FOXP2 | AACTATGAAACAAATTTTCCT | X-ray | 1.90 | Domain-swapped dimer | (63) |
| 2AS5 | FOXP2/NFAT | AACTATGAAACAAATTTTCCT | X-ray | 2.70 | Heterodimer, with PPIs | (90) |
| 3QRF | FOXP3/NFAT | AACTATGAAACAAATTTTCCT | X-ray | 2.80 | Heterotrimer, With PPIs | (64) |
| 4WK8 | FOXP3 | AACTATGAAACAAATTTTCCT | X-ray | 3.40 | Domain-swapped dimer | (91) |