Figure 1.

(A) Overview of the generation of a feature matrix from scRNA-seq data. (i, ii) If a gene-cell expression matrix is provided, EEI is calculated, and highly mutually exclusive gene pairs are extracted. (iii) The feature matrix is generated by merging the expression ratio matrix for EEI pairs with the gene-cell expression matrix. (iv) Dimension reduction is performed using SVD and UMAP with the feature matrix as an input. (B) Summary of the six scRNA-seq datasets. This contains the number of genes that expressed in at least one cell, the number of cells, the number of total reads, the units of transcript counts and the reference.