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Stability of full-length sense strands after incubation of linear GalNAc-siRNA si-3 and GalNAc-sciRNAs with cyclic sense strands si-4 and si-5 in plasma and liver homogenate measured using LC–MS. Percent of full-length sense strand remaining (log10) in (A) rat plasma or (B) rat liver homogenate. Plotted are means with error bars as standard deviation of three replicates per time point.
