Figure 5.
Base pairing is disrupted by cyclization of the sense strand. Imino base-pair regions of 1D 1H NMR spectra of linear GalNAc-siRNAs (si-1, si-2, si-3 and si-6) and GalNAc-sciRNA duplexes with cyclic sense strands (si-4 and si-5).
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