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. 2021 Apr 9;49(18):10524–10541. doi: 10.1093/nar/gkab249

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — 1,6-HD treatment alters the strength of A and B compartments. (A) Visualization of Control, Hex5, and Recovery contact matrices at a 100-kb resolution. The compartment profiles are shown below the maps. (B) Dependence of contact probability, P_c(s), on genomic distance, s, for Control, Hex5, and Recovery samples. Black lines show the slopes for P_c(s) = s⁻^0.75 and P_c(s) = s⁻^1.5. A magnified view of a section of the graph is presented in the top-right corner of the picture. Note that the Control and Hex5 curves are almost completely merged. (C) Ratio between cis (intrachromosomal) and trans (interchromosomal) contacts in Control, Hex5 and Recovery contact matrices. (D) Heatmaps (saddle plots) showing log₁₀ values of contact enrichments between genomic regions belonging to A and B compartments. (E) Compartment strength in cis in Control, Hex5, and Recovery contact matrices. ****P < 0.0001, **P < 0.01, n.s. – non-significant difference in a Mann–Whitney U-test.