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. 2021 Apr 9;49(18):10524–10541. doi: 10.1093/nar/gkab249

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Pentad analysis of A and B compartments upon 1,6-HD treatment. (A) Schematic representation of the principal of pentad analysis. (B) Plots (pentads) showing the observed-over-expected contact frequencies inside the A and B compartments at short (A, B; compartmental domains) and large genomic distances (AA, BB) and between compartments (AB). (C) Pairwise subtractions of Control, Hex5, and Recovery pentads. (D) Boxplots showing the contact frequencies between the A and B compartments. ****P < 0.0001 in a Mann–Whitney U-test.