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Schematic summarizing all of the obtained results. LLPS is a part of a ‘check-and-balances system’ of different forces shaping the 3D genome. LLPS disruption affects the system, resulting in the partial compromise of nucleosome clutch assemblies, decrease in compartment strength, and enhancer-promoter communication. LLPS restoration in such an unbalanced system does not allow chromatin to adopt its initial configuration but results in a new configuration.
