Table 1.

Putative functional impact of alternative splicing of both non-symmetrical exons and poison exons in primary B or EBV-infected B cells. Non-symmetric exons as well as PTC-containing ASEs (poison exons) from our panel of validated events were identified using FasterDB (http://fasterdb.lyon.unicancer.fr/; (83)). Affected exons are identified by their given number in FasterDB, and the corresponding ΔPSI sign indicated. In several cases, the predicted impact (i.e. NMD trigger or truncated protein genesis) has previously been reported, thereby supporting our predictions. Corresponding bibliographic references are as follows: (a) Fidaleo et al. (84); (b) Hubert et al. (85); (c) Barbier et al. (86); (d) Boutz et al. (87); (e) Sun et al. (88); (f) Moutarda-Maarabouni et al. (89); (g) Hyvönen et al. (90); (h) Lareau et al. (66); (i) Sureau et al. (91); (j) Ni et al. (68). * indicates an ASE not reported in FasterDB.

Gene symbol	exon	ΔPSI	Primary B cells	Infected B cells
ACAA1	7	+	NMD
BEND5*	5	+	NMD
CHD1L*	11	+	NMD
HNRNPH1	5	+	NMD (i)
HNRNPH3*	3	+	NMD
HRAS	5	-	NMD (c)
HSD17B4*	26	+	NMD
PMPCB*	7	+	NMD
PTBP2	12	+	NMD (d, i)
RBM5	6	+	NMD (e)
RBM10	6	+	NMD (e)
SIGIRR*	9	-		NMD
SRSF2	3	+	NMD (h, i)
DHX9	7	-	NMD/poison exon (a)
IVNSIABP	8	-	NMD/poison exon
NAA25	17	-	NMD/poison exon
PARP11	2	+		NMD/poison exon
PRPF3	4	-	NMD/poison exon
SAT1	4	-	NMD/poison exon (g)
SFRS17A	5	-	NMD/poison exon
SNRNP70	8	-	NMD/poison exon
SRSF7	4	-	NMD/poison exon (h, j)
ABHD10	2	+	N-ter truncated protein
IRF4	2	+	N-ter truncated protein
IRF7	6	+	N-ter truncated protein
NKTR	6	-	N-ter truncated protein
DOK1	5	+	C-ter truncated protein (b)
RBM5	6	+	C-ter truncated protein (f)
FAM36A	2	+	Changes the coding frame
MED31	3	-	Changes the coding frame