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. 2021 Oct 10;41:100424. doi: 10.1016/j.dmpk.2021.100424

Fig. 1.

Fig. 1

Structure of the drugs. For both mRNA designs, S–2P spike proteins were modified by 2 proline substitutions to produce prefusion-stabilized SARS-CoV-2 spike proteins. UTR, untranslated region; ORF, open reading frame.