Table 1.
MIC values of formycin A (FA), formycin B (FB), and hadacidin (Hada) against H. pylori strains. The results are presented as the geometrical mean of repetitions
| Inhibitors | H. pylori ATCC 26695 strain | H. pylori SS1 strain | |||||
|---|---|---|---|---|---|---|---|
| Ki (µM) | MIC (µg mL−1) | MIC (mM) | FICI | MIC (µg mL−1) | MIC (mM) | FICI | |
| FA | 14.0 ± 1.7 | ≥ 870 | ≥ 3.1 | - | > 1000 | > 3.5 | - |
| FB | 0.96 ± 0.08 | > 1000 | > 3.7 | - | ≥ 397 | ≥ 1.5 | - |
| Hada | 0.19 ± 0.02 | > 1000 | > 8.4 | - | > 1000 | > 8.4 | - |
| FA/FB 1:1 | - | 500/500 | 1.8/1.9 | 1.1 | 177/177 | 0.6/0.7 | 0.6 |
| FA/Hada 1:1 | - | > 500/500 | > 1.8/4.2 | > 1.1 | > 500/500 | > 1.8/4.2 | > 1.0 |
| FB/Hada 1:1 | - | > 500/500 | > 1.9/4.2 | > 1.0 | > 500/500 | > 1.9/4.2 | > 1.8 |