Table 2.
Correlation of the expression of FHOD1 and FMNL1 with clinical variables
| FMNL1 central | FMNL1 peripheral | FMNL1 strongesta | FHOD1 central | FHOD1 peripheral | FHOD1 strongesta | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neg/weak | Interm | Strong | p value | Neg/weak | Interm | Strong | p value | Neg/weak | INTERM | Strong | p value | Neg/weak | Interm./strong | p value | Neg/weak | Interm./strong | p value | Neg/weak | Interm./strong | p value | |
| T | |||||||||||||||||||||
| T1 | 11 (13.4) | 5 (7.0) | 0 (0.0) | 0.700 | 11 (21.6) | 3 (3.8) | 0 (0.0) | 0.023 | 10 (18.9) | 6 (5.9) | 0 (0.0) | 0.128 | 2 (5.7) | 14 (12.0) | 0.069 | 1 (6.3) | 12 (10.1) | 0.919 | 1 (6.3) | 15 (10.2) | 0.789 |
| T2 | 15 (18.3) | 10 (14.1) | 1 (14.3) | 10 (19.6) | 13 (16.5) | 0 (0.0) | 11 (20.8) | 16 (15.8) | 1 (9.1) | 9 (25.7) | 16 (13.7) | 2 (12.5) | 22 (18.5) | 2 (12.5) | 25 (17.0) | ||||||
| T3 | 33 (40.2) | 31 (43.7) | 4 (57.1) | 19 (37.3) | 34 (43.0) | 3 (50.0) | 20 (37.7) | 44 (43.6) | 5 (45.5) | 18 (51.4) | 46 (39.3) | 8 (50.0) | 47 (39.5) | 9 (56.3) | 59 (40.1) | ||||||
| T4 | 23 (28.0) | 25 (35.2) | 2 (28.6) | 11 (21.6) | 29 (36.7) | 3 (50.0) | 12 (22.6) | 35 (34.7) | 5 (45.5) | 6 (17.1) | 41 (35.0) | 5 (31.3) | 38 (31.9) | 4 (25.0) | 48 (32.7) | ||||||
| Stage | |||||||||||||||||||||
| I | 22 (26.8) | 12 (16.9) | 0 (0.0) | 0.032 | 19 (37.3) | 12 (15.2) | 0 (0.0) | 0.033 | 19 (35.8) | 17 (16.8) | 0 (0.0) | 0.004 | 8 (22.9) | 26 (22.2) | 0.750 | 2 (12.5) | 30 (25.2) | 0.636 | 2 (12.5) | 34 (23.1) | 0.660 |
| II | 30 (36.6) | 30 (42.3) | 5 (71.4) | 18 (35.3) | 33 (41.8) | 3 (50.0) | 16 (30.2) | 44 (43.6) | 6 (54.5) | 16 (45.7) | 44 (37.6) | 8 (50.0) | 43 (36.1) | 6 (37.5) | 58 (39.5) | ||||||
| III | 27 (32.9) | 26 (36.6) | 0 (0.0) | 11(21.6) | 30 (38.0) | 2 (33.3) | 16 (30.2) | 36 (35.6) | 2 (18.2) | 10 (28.6) | 40 (34.2) | 5 (31.3) | 38 (31.9) | 7 (43.8) | 47 (32.0) | ||||||
| IV | 3 (3.7) | 3 (4.2) | 2 (28.6) | 3 (5.9) | 4 (5.1) | 1 (16.7) | 2 (3.8) | 4 (4.0) | 3 (27.3) | 1 (2.9) | 7 (6.0) | 1 (6.3) | 8 (6.7) | 1 (6.3) | 8 (5.4) | ||||||
| Location | |||||||||||||||||||||
| Distal oesophagus | 9 (11.0) | 8 (11.3) | 1 (14.3) | 0.817 | 7 (13.7) | 10 (12.7) | 0 (0.0) | 0.500 | 6 (11.3) | 11 (10.9) | 1 (9.1) | 0.713 | 5 (14.3) | 13 (11.1) | 0.378 | 3 (18.8) | 13 (10.9) | 0.151 | 1 (6.3) | 17 (11.6) | 0.509 |
| GOJ/cardia | 28 (34.1) | 25 (35.2) | 2 (28.6) | 13 (25.5) | 32 (21.5) | 2 (33.3) | 15 (28.3) | 39 (38.6) | 3 (27.3) | 13 (37.1) | 36 (30.8) | 6 (37.5) | 42 (35.3) | 5 (31.3) | 50 (34.0) | ||||||
| Corpus | 19 (23.2) | 21 (29.6) | 3 (42.9) | 15 (29.4) | 17 (21.5) | 3 (50.0) | 15 (28.3) | 24 (23.8) | 5 (45.5) | 11 (31.4) | 30 (25.6) | 6 (37.5) | 29 (24.4) | 7 (43.8) | 37 (25.2) | ||||||
| Antrum/pylorus | 26 (31.7) | 17 (23.9) | 1 (14.3) | 16 (31.4) | 20 (25.3) | 1 (16.7) | 17 (32.1) | 27 (26.7) | 2 (18.2) | 6 (17.1) | 38 (32.5) | 1 (6.3) | 35 (29.4) | 3 (18.8) | 43 (29.3) | ||||||
| P53 | |||||||||||||||||||||
| Mutant–type | 51 (62.2) | 37 (52.1) | 4 (57.5) | 0.465 | 32 (62.7) | 46 (59.0) | 4 (66.7) | 0.909 | 35 (66.0) | 54 (54.0) | 6 (54.5) | 0.347 | 27 (77.1) | 60 (51.3) | 0.007 | 11 (68.8) | 67 (56.8) | 0.362 | 13 (81.3) | 80 (54.8) | 0.042 |
| Wild-type | 31 (37.8) | 34 (47.9) | 3 (42.9) | 19 (37.3) | 32 (41.0) | 2 (33.3) | 18 (34.0) | 46 (46.0) | 5 (45.5) | 8 (22.9) | 57 (48.7) | 5 (31.3) | 51 (43.2) | 3 (18.8) | 66 (45.2) | ||||||
| MMR | |||||||||||||||||||||
| MMR-D | 10 (12.2) | 4 (5.6) | 0 (0.0) | 0.252 | 5 (9.8) | 5 (6.4) | 0 (0.0) | 0.697 | 6 (11.3) | 8 (8.0) | 0 (0.0) | 0.591 | 1 (2.9) | 13 (11.1) | 0.191 | 0 (0.0) | 10 (8.5) | 0.608 | 0 (0.0) | 14 (9.6) | 0.364 |
| MMR-P | 72 (87.8) | 67 (94.4) | 7 (100) | 46 (90.2) | 73 (93.6) | 6 (100) | 47 (88.7) | 92 (92.0) | 11(100) | 34 (97.1) | 104 (88.9) | 16 (100) | 108 (91.5) | 16 (100) | 132 (90.4) | ||||||
| EBV | |||||||||||||||||||||
| Positive | 5 (6.1) | 6 (8.5) | 2 (28.6) | 0.112 | 4 (7.8) | 4 (5.1) | 1 (16.7) | 0.361 | 3 (5.7) | 8 (8.0) | 3 (27.3) | 0.090 | 2 (5.7) | 10 (8.5) | 0.734 | 0 (0.0) | 12 (10.2) | 0.359 | 1 (6.3) | 13 (8.9) | < 0.999 |
| Negative | 77 (93.9) | 65 (91.5) | 5 (71.4) | 47 (92.2) | 74 (94.9) | 5 (83.3) | 50 (94.3) | 92 (92.0) | 8 (72.7) | 33 (94.3) | 107(91.5) | 16 (100) | 106 (89.8) | 15 (93.8) | |||||||
Statistically significant p values are indicated in bold
MMR-D mismatch repair deficient, MMR-P mismatch repair proficient, EBV Epstein–Barr virus
aSample with the strongest intensity, central or peripheral