Table 5.

Multivariate cox regression analysis of EORTC QLQ-C30 and OG25 symptom and functioning scales and items for patients with advanced disease

Multivariate cox regression analysis	Patients with advanced disease
Single HRQoL items adjusted for clinical variables	HR (99% CI)	p
Summary score	0.75 (0.59–0.94)	0.001
Global health status	0.88 (0.75–1.04)	0.05
Physical functioning	0.91 (0.77–1.09)	0.19
Role functioning	0.89 (0.80–1.00)	0.008
Fatigue	1.16 (1.03–1.31)	0.002
Nausea and vomiting	1.13 (0.98–1.29)	0.02
Pain	1.16 (1.02–1.32)	0.003
Insomnia	1.13 (1.02–1.25)	0.002
Appetite loss	1.08 (1.00–1.18)	0.01
Eating restrictions	1.07 (0.98–1.18)	0.05
Dry mouth	1.07 (0.97–1.18)	0.06
Body image	1.05 (0.95–1.16)	0.21
Worrying about weight loss	1.06 (0.98–1.15)	0.05

HRQoL health-related quality of life. HR  hazard ratio. Values in bold were statistically significant at p < 0.01. Hazard ratios are given for every 10-point increase in HRQoL scores. Clinical covariates for the advanced subgroup were treatment type, performance status, peritoneal metastases, age, and marital status