Table 4.

Prognostic factors for OS in patients with GRC based on univariable and multivariable Cox regression analyses

Variable	Univariable p value	Multivariable p value	Hazard ratio (95% CI)
Gender	0.504	–	–
Age	0.597	–	–
Year of GRC surgery	0.602	–	–
Type of initial gastrectomy (BII vs. other resections)	0.263	–	–
Histology of initial gastrectomy (benign vs. malign)	0.561	–	–
Time interval (initial gastrectomy to surgery for GRC)	0.964	–	–
Type of GRC gastrectomy (total vs. subtotal)	0.457	–	–
Multivisceral resection	0.424	–	–
Laurén’s type (diffuse vs. non-diffuse)	0.270	–	–
Signet ring cell carcinoma	0.573	–	–
AJCC/UICC stage	< 0.001	< 0.001	1.615 (1.285–2.029)
pT category	0.001	–	–
pN category	< 0.001	–	–
M category	0.287	–	–
Resection margins (R+ vs. R0)	0.001	–	–
Overall complications	< 0.001	< 0.001	2.911 (1.616–5.243)
Major surgical complications	0.009	–	–

AJCC American Joint Committee on Cancer, CI confidence interval, GRC gastric remnant cancer, OS overall survival, UICC Union for International Cancer Control

p values in bold type indicate statistical significance