Fig. 1.

Illustration of the structure of the analyzed patient collectives categorized into gastric carcinoma and the esophageal adenocarcinoma. The gastric carcinomas were divided into the four molecular subgroups (according to TCGA). This revealed an accumulation and special prognostic relevance of the TANs in the CIN subgroup. Adenocarcinomas of the esophagus show the same molecular characteristics as the CIN subgroup of the stomach and are therefore particularly well suited as a “validation”. Both collectives were divided into two cohorts: primarily operated patient cohorts and neoadjuvant-treated patient cohorts. Nothing is known about the significance and distribution of TANs in the adenocarcinoma of the esophagus, the neoadjuvant-treated carcinomas nor in the different molecular subgroups of gastric carcinoma. TCGA The Cancer Genome Atlas