Table 2.

Linear regression of full WAIS IQ on PRS adjusted on age, sex and population structure.

FIQ ~ PRS GWAS	GWAS SS	P-val-T	ES*	SE*	R2	R2a*	P	FDR P
Schizophrenia	150 064	0.1	−0.296	0.120	0.169	0.049	0.016	0.048
Schizophrenia resilience	66 617	0.01	0.350	0.114	0.197	0.081	0.003	0.014
ADHD	55 374	1.0E−07	0.136	0.104	0.129	0.003	0.197	0.222
Bipolar disorder	51 710	0.1	−0.250	0.190	0.130	0.004	0.191	0.222
Major depression	480 359	1.0E−05	−0.215	0.113	0.147	0.024	0.061	0.110
Cross-disorder 2	727 126	1.0E−03	0.073	0.108	0.117	-0.010	0.500	0.500
Intelligence	269 867	1.0E−04	0.198	0.104	0.147	0.024	0.060	0.110
Educational attainment	766 345	1.0E−06	0.178	0.101	0.142	0.018	0.081	0.122
Cognitive performance	257 828	0.3	0.349	0.102	0.216	0.102	0.001	0.009

GWAS SS: discovery sample size of the GWAS.

P-val-T: best fit p value threshold.

ES: effect size (coefficient in the linear regression model after stardardizing the variables).

R²a: adjusted R square, the variance explained by PRS. P values and corrected P values (FDR P) are highlighted in bold if they are < 0.05.

ADHD attention deficit hyperactivity disorder, SE standard error.