FIGURE 7.

Effects of Oxy210 on pro‐inflammatory cytokines and inflammasome gene expression. Expression of pro‐inflammatory genes, Il6(A), and MCP‐1 (official gene name Ccl2, B) and Tnfa (C) in the livers from control and Oxy210‐fed mice (8–10 mice in each group) was measured by qPCR and normalized to the level of the housekeeping gene Oaz1. Relative gene expression levels are presented as mean ±SD. Plasma levels of IL‐6 (D), MCP‐1 (E) and TNF‐α (F) were measured by ELISA. Data are mean ± SEM from 8 mice per group. Liver expression of Nlrp3 (G) and Casp1 (H) was measured by quantitative PCR and normalized to Oaz1. Data are presented as mean ± SD from 8 to 10 mice per group. *denotes p < 0.05, ** denotes p < 0.01 and ***denotes p < 0.001 versus control