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. 2021 Oct 9;19:417. doi: 10.1186/s12967-021-03087-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Weighted gene co-expression network analysis (WGCNA) identified hub genes of renal cell carcinoma. A Analysis of Scale independence and mean connectivity for various soft-thresholding power. B The 26 gene dendrogram and module colors of DEGs based on TOM. C, D The eigengene adjacency heatmap and clustering of module eigengene to display the relationships between each module. E The relationships between 25 modules and clinical traits including T, N, M Stage and G grades. The pink module was selected as the most significant module. F The relationships between the genes in pink module and gene significance for M stage, T stage, Stage, and G grade. G The network of ten top hub genes by Cytoscape software. DEGs: differentially expressed genes; TOM: topological overlap matrix