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. 2021 Oct 9;19:417. doi: 10.1186/s12967-021-03087-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CENPA accelerated the cell cycle and activated the Wnt signaling pathway. A The GSEA results of CENPA using TCGA-KIRC expression dataset. 533 tumoral samples was divided into two groups based on CENPA level. Genes expression patterns of two groups was different in cell cycles and Wnt pathway. B The expression of WNT5A is positively correlated to the expression of CENPA in TCGA-KIRC ccRCC tissues. C, D The expression of cyclin D1(CCND1) and β-catenin (CTNNB1) were down-regulated or upregulated in ccRCC cells with knockdown or overexpression of CENPA. E Western blot revealed the expression of CTNNB1 in the cytoplasm and nucleus. β-actin and Lamin B1 were used as internal references in the cytoplasm and nucleus, respectively. F–G Cell cycle distribution was analyzed by PI staining in Caki-1 cells after transfection by Si-CENPA or CENPA plasmid for 48 h. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Error bars indicate mean ± SD