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. 2021 Oct 9;19:311. doi: 10.1186/s12951-021-01058-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Schematic illustration of Fe₃O₄@PCBMA-SIM nanoparticles killing cancer cells (A); The degradation property of Fe₃O₄@PCBMA nanoparticles dispersed in different concentrations of GSH (0 mM and 10 mM) and pH values (5.0, 6.5 and 7.4) (B); Cumulative SIM releasing from Fe₃O₄-SIM and Fe₃O₄@PCBMA-SIM nanoparticles dispersed in 10 mM GSH (C); Cell viability of the MCF-7 (D) and MDA-MB-231 (E) cells after 48 h incubation with Fe₃O₄, Fe₃O₄@PCBMA, SIM, Fe₃O₄-SIM and Fe₃O₄@PCBMA-SIM suspensions; CLSM of control, Fe₃O₄@PCBMA, free SIM, Fe₃O₄-SIM and Fe₃O₄@PCBMA-SIM nanoparticles after uptake by MCF-7 and MDA-MB-231 cells (F)