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. 2021 Oct 9;21:525. doi: 10.1186/s12935-021-02232-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — AL355338 facilitated aggressive phenotypes and glycolytic metabolism of NSCLC cells. A–C The migratory and invasive activities of AL355338 was detected by transwell assays in A549 and PC9 cells transfected with AL355338 siRNAs or si-NC. Representative images and quantitative analysis were shown. Scale bar, 50 μm. D–F Representative images and quantitative analysis of wound healing assays for the indicated cells. Scale bar, 100 μm. G Western blot analysis was performed to detect EMT markers (E-cadherin, N-cadherin, Vimentin) in indicated cells. H HK2, PKM2 and LDHA protein expressions were examined under AL355338 knockdown conditions by western blotting. I ¹⁸F-FDG uptake level was detected in A549 and PC9 cells transfected with AL355338 siRNAs or si-NC. J Lactate release level was measured for the indicated cells. K ATP production level was determined for the indicated cells. Data shown are mean ± SD (n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001)