TABLE 1.
Demographic characteristics in Asian (Parts A, B, and C) and non‐Asian (Part E) subjects (safety analysis set)
| Asian subjects (Parts A, B, C) | Napabucasin (mg) | Placebo (pooled) | |||||
|---|---|---|---|---|---|---|---|
| 80 mg | 160 mg | 240 mg | 480 mg | 720 mg | 1200 mg | ||
| (N = 1) | (N = 1) | (N = 9) | (N = 9) | (N = 9) | (N = 9) | (N = 14) | |
| Sex (male), n (%) | 1 (100.0) | 1 (100.0) | 6 (66.7) | 6 (66.7) | 6 (66.7) | 6 (66.7) | 10 (71.4) |
| Age (y) | |||||||
| Mean (SD) | 21 (N/A) | 22 (N/A) | 23.9 (5.3) | 27.8 (4.3) | 24.6 (4.3) | 28.0 (5.3) | 26.0 (6.2) |
| Median (range) | N/A | N/A | 21 (20–33) | 27 (20–34) | 23 (20–31) | 26 (23–37) | 25 (20–38) |
| Not Hispanic or Latino ethnicity, n (%) | 1 (100.0) | 1 (100.0) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 14 (100.0) |
| Asian race, n (%) | 1 (100.0) | 1 (100.0) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 14 (100.0) |
| Weight (kg) | |||||||
| Mean (SD) | 76.2 (N/A) | 61.3 (N/A) | 57.1 (4.6) | 57.7 (8.5) | 56.9 (8.1) | 61.4 (3.5) | 61.6 (6.8) |
| Median (range) | N/A | N/A | 55.7 (50.5–64.2) | 56.1 (45.1–74.4) | 57.9 (45.3–68.8) | 61.5 (55.3–66.8) | 63.3 (50.4–72.1) |
| BMI (kg/m2) | |||||||
| Mean (SD) | 24.0 (N/A) | 22.6 (N/A) | 20.7 (1.1) | 21.1 (2.2) | 20.7 (1.3) | 22.0 (1.7) | 21.6 (1.7) |
| Median (range) | N/A | N/A | 20.8 (19.1–22.2) | 20.3 (18.6–25.0) | 20.8 (19.3–22.9) | 22.7 (19.5–24.2) | 22.0 (18.9–24.0) |
| Non‐Asian subjects (Part E) | (N = 6) | (N = 6) | (N = 6) | ||||
|---|---|---|---|---|---|---|---|
| Sex (male), n (%) | 6 (100.0) | 6 (100.0) | 6 (100.0) | ||||
| Age (y) | |||||||
| Mean (SD) | 22.5 (4.0) | 29.2 (7.6) | 29.0 (4.3) | ||||
| Median (range) | 24 (22–33) | 26.5 (22–40) | 30 (23–33) | ||||
| Hispanic or Latino ethnicity, n (%) | 2 (33.3) | N/A | 1 (16.7) | ||||
| Not Hispanic or Latino ethnicity, n (%) | 4 (66.7) | 6 (100.0) | 5 (83.3) | ||||
| Caucasian race, n (%) | 6 (100.0) | 6 (100.0) | 6 (100.0) | ||||
| Weight (kg) | |||||||
| Mean (SD) | 65.0 (7.6) | 77.2 (11.0) | 75.1 (10.0) | ||||
| Median (range) | 63.5 (58.6–79.6) | 78.4 (60.2–90.8) | 75.0 (63.0–87.2) | ||||
| BMI (kg/m2) | |||||||
| Mean (SD) | 20.9 (2.4) | 22.1 (1.5) | 24.0 (2.6) | ||||
| Median (range) | 20.6 (18.3–24.3) | 22.7 (19.7–23.7) | 23.8 (20.7–27.2) | ||||
Abbreviations: BMI, body mass index; N/A, not available; SD, standard deviation.